TRIM63 and cancer: Atrogin-1 and MuRF-1 were two key muscle-specific E3 ubiquitin ligases regarded as the markers of muscle atrophy, and also proved to be related to the mechanisms of BJD improving muscle atrophy in cancer cachexia (Bodine and Baehr, 2014; Zhang et al., 2017; Zhang et al., 2018; Wang et al., 2020).