The therapeutic effect of Qishen granule (QSG) on myocardial ischemia was to inhibit cardiomyocyte apoptosis by increasing the levels of Bcl-2 and caspase-3/12 and decreasing the expression of Bax and cleaved caspase-3/12 (Zhang et al., 2020a). Here, CASP3 is linked to myocardial ischemia.