VEGFA and neoplasm: Bevacizumab has been proven effective in dealing with tumor-associated brain edema and radiation-induced brain necrosis by blocking the VEGF/VEGFR signal transduction, repairing the abnormal blood vessels, and decreasing vascular permeability (Gonzalez et al., 2007; Sadraei et al., 2015; Shen et al., 2015).