Based on the above analysis results, the anti-BRCA/COVID-19 effect of Diosmetin may be regulated by core genes, including EGFR, PIK3R1, SRC, AKT1, APP, AR, FYN, PTPN1, CDK1, and GSK3B. Through further verification of molecular docking, we determined that the small molecule ligands bound well to protein molecule receptors, which indicates that Diosmetin has a certain effect on the 7MEQ structure of TMPRSS2 protein, an important protein of COVID-19. The gene discussed is AKT1; the disease is COVID-19.