Strong evidence now indicates that chronic inflammation, as determined by increasing levels of key soluble pro-inflammatory cytokines such as tumor necrosis factor -α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), plays an important role in the development of various neurological disorders, including neonatal HIBD (Li et al., 2020; Khodarahmi et al., 2021; Yu et al., 2021). This evidence concerns the gene TNF and nervous system disorder.