DAT is regulated by different presynaptic proteins, including DRD2 and DRD3 (acting as sensors of extracellular DA concentration, regulating the synthesis and release of DA), and abnormal DAT function is closely associated with several neurodegenerative diseases and psychiatric disorders (Rouge-Pont et al., 2002; Sokoloff et al., 2006). The gene discussed is SLC6A3; the disease is neurodegenerative disease.