Inoue et al. have shown that transmembrane protein 132D (TMEM132D), COMT, and GABA receptor alpha 6 subunits (GABRA6) genotypes are associated with emotional processing in the cingulate, frontal cortex, and hippocampus in panic disorder and major depressive disorder (MDD) (Papaleonidopoulos et al., 2018). Here, TMEM132D is linked to major depressive disorder.