The present study found that the expressions of GLUT2, GLUT4, FAS, and ACC significantly decreased in the liver of T2DM rats compared with the control rats, while no significant differences in the expressions of genes involved in glucose metabolism, including PK, PC, PEPCK, and GSK-3β were found between rats in the CON and T2DM groups. Here, PCK2 is linked to type 2 diabetes mellitus.