Bone-derived IGF-I connected with bone and metastasized the tumor cells via IGF-IR/Akt/NF-κB signaling, while BMP9 was able to inhibit the migration involving SDF-1/CXCR4-PI3K pathway, which was associated with PMBN regulation (Hiraga et al., 2012; W. Wang et al., 2015). The gene discussed is AKT1; the disease is neoplasm.