We are concerned about that PRMT5 plays an important role in human cancers by promoting the cell proliferation, invasion, and migration, besides, PRMT5 inhibition was efficacious ameliorate leukocyte and platelet counts, hepatosplenomegaly, and fibrosis in the MPLW515L model of myelofibrosis. This evidence concerns the gene PRMT5 and myelofibrosis.