However, LDHA was found to be highly expressed in most cancer cells, which is the main reason why LDHA can be used as a biomarker of many malignant tumors, such as gastric cancer (Kolev et al., 2008), testicular germ cell tumor (Augoff and Grabowski, 2004), glioma (Hu S. et al., 2016) and melanoma (Brand et al., 2016). Here, LDHA is linked to central nervous system cancer.