Downregulated pathways were as follows: graft versus host disease, intestinal immune network for IgA production, primary immunodeficiency, asthma, allograft rejection, autoimmune thyroid disease, natural killer cell-mediated cytotoxicity, type I diabetes mellitus, and lysosome in C1; complement and coagulation cascades, and drug metabolism cytochrome P450 in C2; ribosome, spliceosome, cell cycle, RNA polymerase, DNA replication, Parkinson’s disease, base excision repair, butanoate metabolism, glycosaminoglycan biosynthesis chondroitin sulfate, and Huntington’s disease in C3 (Figure 10B). Here, CD79A is linked to autoimmune thyroid disease.