Downregulated pathways were as follows: graft versus host disease, intestinal immune network for IgA production, primary immunodeficiency, asthma, allograft rejection, autoimmune thyroid disease, natural killer cell-mediated cytotoxicity, type I diabetes mellitus, and lysosome in C1; complement and coagulation cascades, and drug metabolism cytochrome P450 in C2; ribosome, spliceosome, cell cycle, RNA polymerase, DNA replication, Parkinson’s disease, base excision repair, butanoate metabolism, glycosaminoglycan biosynthesis chondroitin sulfate, and Huntington’s disease in C3 (Figure 10B). The gene discussed is CD79A; the disease is inborn error of immunity.