Among them, the infiltration levels of CD8+ T cells, regulatory T cells (Tregs), gamma delta T cells, Monocytes, M1 macrophages, resting dendritic cells, activated dendritic cells, activated mast cells, eosinophils and neutrophils were markedly higher in AD patients (Figure 3B), indicating the altered activity of immune system might be involved in the onset and progression of AD. The gene discussed is CD8A; the disease is Alzheimer disease.