TMEM67 and Alzheimer disease: Figure 6A showed the force plot for a patient individual, which is predicted by the expression of ER stress DEGs. The expression of RNF188, FGF21, TMEM67, FBXO27, NGLY1, CREB3L3 were regarded as the major influential factors concerning AD progression. Figure 6B exhibited the profile of a normal subject. The model considered the expression of DDX3X, SEL1L2, UBAC2, UBEB4 as the apparent influential factors reducing this risk of AD occurrence. Figure 6C depicted the global interpretation for all the samples (including normal and patient subjects) in the testinging set.