Relevant researches demonstrated that AD patients and mouse exhibited persistent changes in ER stress pathways including the enhanced phosphorylation of PERK and its downstream molecular eIF2alpha, as well as the increased activity of ATF4 and CHOP, which are positively correlation with the severity of AD (Braak scores) (Marwarha et al., 2017). The gene discussed is ATF4; the disease is Alzheimer disease.