Knockout of LSD1 or inhibition of LSD1 activity can also enhance the immune response of T cells in various cancers, such as cervical, ovarian, gastric, and oral cancers (Soldi et al., 2020; Xu et al., 2021; Alhousami et al., 2022; Shen et al., 2022). This evidence concerns the gene KDM1A and lip and oral cavity carcinoma.