LSD1 regulates different signalling pathways, such as the Wnt/β-Catenin, PI3K/AKT signalling, EMT-related, Notch signalling and ubiquitin–proteasome pathway, and target proteins, such as the classic cancer suppressor star protein p53, HIFs, and immune checkpoints, in different types of cancer to mediate cancer progression. Here, TP53 is linked to cancer.