Some examples include SOX2, which maintains cancer cell stemness; sex hormone receptors (AR and ER); the transcriptional repressor ZNF516; retinoic acid-related orphan receptor alpha (RORα); aryl hydrocarbon receptors; ubiquitin-specific protease 28 and miRNAs (Park et al., 2016; Bai et al., 2017; Khanal et al., 2017; Kim et al., 2017; Li et al., 2017; Macheleidt et al., 2018; Cuyàs et al., 2020; Yu et al., 2020; Zhang et al., 2021). This evidence concerns the gene ZNF516 and cancer.