TNF and diabetic kidney disease: Khan et al. (2020) found that stigmasterol significantly suppresses the inflammation by decreasing the expression of proinflammatory mediators (TNF, IL-6, IL-1B) and increasing the expression of anti-inflammatory cytokine (IL-10) in collagen-induced arthritis. And Kishore demonstrated that stigmasterol might inhibit the progression of DKD by ameliorating oxidative stress (Kishore et al., 2016). In general, our analysis shows that poricoic acid C and stigmasterol may play a protective role in DKD through anti-inflammatory and anti-lipid deposition via TNF and PPARG.