TYRO3 and leiomyosarcoma: In leiomyosarcoma patients, especially those whom develop metastasis, express higher levels of Tyro3 and Gas6, and crizotinib and foretinib showed effective antitumor activity in leiomyosarcoma through Tyro3 and Axl deactivation (Dantas-Barbosa et al., 2017).