HAVCR2 and neoplasm: Interestingly, Tim-3 is overexpressed in RCC tumor tissues, and overexpression of Tim-3 predicts better DFS and OS and has no significant correlation with the TNM classification and tumor grade (data not shown); this may partially explain the results that dual blockade of PD-1 and LAG-3, but not PD-1 and Tim-3, is a promising checkpoint blockade combination strategy (Zelba et al., 2019).