Propofol alleviates pulmonary inflammation in a respiratory distress model (Haitsma et al., 2009) and reduces endotoxin inflammation by inhibiting the production of ROS and downstream protein kinase B (AKT)/inhibitor of κB kinase (IKK β)/NF-κB signaling (Hsing et al., 2011). Here, AKT1 is linked to Respiratory distress.