Propofol effectively inhibits the growth of hepatocellular carcinoma in vivo and stimulates the migration of miR-142-3p from macrophages to hepatocellular carcinoma (HCC) cells in vitro by down-regulating Ras-related C3 botulinum toxin substrate 1 (RAC1) and inhibiting the migration and proliferation of HCC cells (Zhang et al., 2014). This evidence concerns the gene RAC1 and hepatocellular carcinoma.