Leuprolide acetate is a type of GnRH agonist that is commonly used for treating patients with endometriosis, uterine myoma with menstruation, abdominal pain, back pain, anemia, premenopausal breast cancer, estrogen receptor-positive prostate cancer, and central precocity (Yasukawa et al., 2005). This evidence concerns the gene GNRH1 and endometriosis.