Treatment with 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside could inhibit hyperglycaemia-induced mRNA and protein expression of AGT, renin, ACE, and AT1R in mice with DN induced by streptozotocin (Chen et al., 2016). The gene discussed is ACE; the disease is Hyperglycemia.