In LoVo and RKO colon cancer cells, PUFAs can reduce the synthesis of PGE2 and LTB4, inhibit the expression of ALOX5, LTB4, mPGES, COX-2, and PGE2, and increase the expression of LXA4, thereby promoting apoptosis and inhibiting the growth of LoVo and RKO colon cancer cells (125). This evidence concerns the gene ALOX5 and colonic neoplasm.