ALOX5 and malignant colon neoplasm: In LoVo and RKO colon cancer cells, PUFAs can reduce the synthesis of PGE2 and LTB4, inhibit the expression of ALOX5, LTB4, mPGES, COX-2, and PGE2, and increase the expression of LXA4, thereby promoting apoptosis and inhibiting the growth of LoVo and RKO colon cancer cells (125).