TNF and colonic neoplasm: Fluckiger et al. (54) reported that the TNFα-dependent manner triggers apoptosis in HCT-116, HCT-8, and human CRC cells in DHA-mediated, and cells induced with DHA increased TNFα mRNA content by downregulating microRNA-21 expression, stating that the effect of TNFα on DHA-mediated apoptosis of colon cancer cells.