• ACPA fine-specificities (30% of ACPA-/RF- patients) IgG/IgA RF (9%) • Anti-CarP (8–11%; not associated with SE, PTNP22 or smoking; present in pre-RA) • AAPAs (30–40%) • Other: anti-PAD4 (2-19%), anti-progranulin (21%), anti-PTX3 (28%), and anti-DUSP11 (32%). This evidence concerns the gene DUSP11 and rheumatoid arthritis.