Importantly, the periodontitis citrullinome paralleled that of RA synovial fluid, including several major RA-specific citrullinated neoantigens that are targeted by ACPAs (e.g., vimentin, actin, α-enolase, histones and others), reinforcing the link between the inflamed gingival mucosa and the rheumatoid joint (67). This evidence concerns the gene VIM and rheumatoid arthritis.