When targeting exon sequencing and RNA sequencing from 9 individuals with either pGGN or part-solid GGN, in addition to EGFR and BRAF, other genes such as isocitrate dehydrogenase (NADP(+)) 2 (IDH2), tumor protein 53 (TP53), phosphatase and tensin homolog (PTEN) and EPH receptor B4 (EPHB4) were also identified as putative driver mutations of GGN adenocarcinomas (61). The gene discussed is EPHB4; the disease is adenocarcinoma.