When targeting exon sequencing and RNA sequencing from 9 individuals with either pGGN or part-solid GGN, in addition to EGFR and BRAF, other genes such as isocitrate dehydrogenase (NADP(+)) 2 (IDH2), tumor protein 53 (TP53), phosphatase and tensin homolog (PTEN) and EPH receptor B4 (EPHB4) were also identified as putative driver mutations of GGN adenocarcinomas (61). This evidence concerns the gene IDH2 and adenocarcinoma.