We found a single cross sectional study, in which immunohistochemistry on skin biopsy sections of 10 SSc patients (6 dcSSc and 4 lcSSc) and 6 controls (3 “inflammatory”- subacute eczema, lichen planus and papular urticaria- and 3 normal) showed a significant upregulation of Endoglin expression on endothelial cells of SSc and inflammatory subjects compared to HCs (36). The gene discussed is ENG; the disease is systemic sclerosis.