A recent study from the PHAROS Registry tried to understand if endothelial biomarkers as ENG and Pentraxin 3 (PTX-3) could detect or be predictive for PAH: of 558 SSc patients the Registry had 118 blood samples and among them they did not find significant differences between SSc-PAH and SSc without PAH (41). The gene discussed is PTX3; the disease is pulmonary arterial hypertension.