The authors demonstrated that, after stimulation by Vascular Endothelial Growth Factor (VEGF) or Endothelin-1 (ET-1, an important mediator of vascular disease in SSc, inducer of collagen in fibroblasts), both BM-MSC and MSC from SSc patients expressed more ENG than controls (30). The gene discussed is EDN1; the disease is systemic sclerosis.