AKIRIN2 is necessary for the growth and metastasis of lung cancer [33] and liver cancer [34] and promotes the angiogenesis of gallbladder cancer through interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3)/vascular endothelial growth factor A (VEGFA) [35]. This evidence concerns the gene STAT3 and lung cancer.