Considering that PAK1 was abnormally expressed in pancreatic cancer and could inhibit DNA damage and inhibit cell apoptosis via the NF-κB pathway, thereby making pancreatic cancer cells resistant to GEM in the previous study, we hypothesized that circLMTK2 might regulate the expression of PAK1 by binding to miR-485-5p through the circRNA-miRNA-mRNA interaction network. This evidence concerns the gene PAK1 and familial pancreatic carcinoma.