In response to these changes, the body system releases proinflammatory cytokines and growth factors, and liver cells increase the production of acute phase proteins, such as CRP, and reduce ALB production [23]; second, liver synthesis of ALB is mainly affected by colloid osmotic pressure and inflammatory state but does not change in nutrient intake and malnutrition state [22, 24]. The gene discussed is ALB; the disease is malnutrition.