Because target genes are regulated via miRNAs by acting on the 3′-end noncoding regions of mRNA encoding genes, further online bioinformatics prediction, luciferase reporter gene, and qPCR detection showed that miR-299-3p regulates the MMP-2 expression through binding in nasopharyngeal carcinoma cells. Here, MMP2 is linked to nasopharyngeal carcinoma.