The results showed that the expression levels of nectin-1 and nectin-4 proteins were low in HCC and normal liver tissues; meanwhile, the expression levels of nectin-2 protein were medium in both HCC and normal liver tissues, and the expression levels of nectin-3 protein were high in HCC but low in normal liver tissues, respectively (Table 2). The gene discussed is NECTIN1; the disease is hepatocellular carcinoma.