STAT3 and neoplasm: Additionally, tumor-related genes with known mutations include some tumor suppressor genes (such as TP53, DDX3X, and MGA), JAK/STAT pathway genes (such as JAK3, STAT3, and STAT5), and some epigenetic modified genes (such as KMT2D, BCOR, ARID1A, and EP300) (4, 17–20).