SCG5 and obesity due to melanocortin 4 receptor deficiency: In order to verify the association of plasma SCG5 with pathology (e.g., cachexia, adipopenia, lipodystrophy, obesity, etc.)and physiology (e.g., body weight, BMI, gender, race, etc.), it will be valuable to explore the association of SCG5 with pathophysiological factors in a large population to overcome any bias linked to genetic and geological backgrounds.