In another study, HIF2α expression was found elevated in M3 and M6 AMLs, as defined by FAB morphological classification, and in AMLs with t(15;17) translocation (generating the PML-RARα oncoprotein), inv(16) and complex karyotype (70), although a functional cooperation of HIF2α with the oncogenic drivers of these AML subtypes was not tested. This evidence concerns the gene EPAS1 and acute myeloid leukemia.