For instance, deletion of the HIF1α gene in mouse hematopoietic stem and progenitor cells alongside retroviral transfer of AML oncogenic drivers (MLL-AF9, AML1-ETO, or MEIS1 and HOXA9) failed to impact leukemia initiation, progression and LSCs self-renewal by serial transplantation experiments (111). This evidence concerns the gene KMT2A and acute myeloid leukemia.