It has been reported that the genes involved in mucin O-glycosylation in LUAD were significantly upregulated, and the immune response in lung squamous cell carcinoma (LUSC) was blocked, indicating that abnormal glycosylation might lead to the biogenesis and progression of non-small cell lung cancer (NSCLC) (21). The gene discussed is MUC5AC; the disease is non-small cell lung carcinoma.