SOX9 (n=4, p=0.04), whose knockdown was previously shown to inhibit chordoma cell growth and induce apoptosis (39), and PARP1 (n=5, p=0.004) and Survivin (n=3,p=0.047), also critical to chordoma cell growth (40), all show decreased expression with selinexor treatment (Figure 3C). The gene discussed is BIRC5; the disease is chordoma.