IREB2 and neoplasm: In different tumor stages, low ACO1 expression was accompanied with worse OS, DSS, and PFI only in stage 1 and 3 patients with KIRC (Supplemental Figure S1), while low IREB2 expression was strongly accompanied with worse OS in stage 1,worse DSS in stage 3, and worse PFI in stage 1 and 3 patients with KIRC (Supplemental Figure S2).