Cyclin D1 upregulation has been seen in at least 11 kinds of cancers, including head and neck squamous cell carcinoma (12), non-small-cell lung cancer (NSCLC) (13), endometrial cancer (14), melanoma (15), pancreatic cancer (16, 17), gastric cancer (18), breast cancer (19), colorectal cancer (20), mantle cell lymphoma (21), multiple myeloma (22), and prostate cancer (23). The gene discussed is CCND1; the disease is cancer.