In the same way, it has been described that adenosine, through A3AR activation, regulates the EMT process in head and neck cancers because the blockade of this adenosine receptor decreased the expression of proteins such as Vimentin, Zeb, Slug, and Twist1, which are essential during the EMT process and the invasiveness of this type of neoplasia (47). This evidence concerns the gene TWIST1 and head and neck cancer.