LncRNA-AC009948.5 could promote the proliferation, invasion, and metastasis of lung adenocarcinoma cells and the occurrence of EMT through various mechanisms, including F-actin polymerization induction, signaling pathways activation, and ceRNA (Figure 5H) (A model that LncRNA-AC009948.5 and NCAPG2 compete for the binding sites of miR-186-5p is proposed). The gene discussed is NCAPG2; the disease is lung adenocarcinoma.