After treatment with the PI3K inhibitor and EGF, the expression levels of E-cadherin and Vimentin recovered, indicating that LncRNA-AC009948.5 could promote EMT in lung adenocarcinoma cells through the PI3K/Akt/GSK3β signaling pathway (Figure 5F, S3B). The gene discussed is CDH1; the disease is lung adenocarcinoma.