RPS14 and infection: In order to further clarify the effects of ZNF280A/RPS14 axis in the regulation of CRC, we analyzed the expression of RPS14 in CRC cells by qPCR (Figure S3A), and constructed RPS14-overexpressed cells, shZNF280A cells, as well as cells with simultaneous RPS14 overexpression and ZNF280A knockdown (Figure S3B for transfection efficiency, Figures S3C, D for expression detection) via lentiviral infection.