QKI and breast carcinoma: (12) have shown that the decreased expression or activity of RASA1 can activate MAPK signaling pathway by reducing the GTPase activity of Ras protein, thereby increasing cell proliferation, inhibiting apoptosis and regulate cell cycle distribution; QKI can directly bind to RASA1 mRNA and enhance RASA1 expression by stabilizing its transcripts, through which QKI overexpression weakens the phosphorylation of MAPK signaling pathway, thereby inhibiting the activation of MAPK pathway and breast cancer progression.