AGAP2 and breast carcinoma: (23) determined that HuR could bind to lncRNA AGAP2-AS1 to stabilize AGAP2-AS1 expression and the AGAP2-AS1-HuR complex upregulates H3K27ac level in MTA1 promoter region to improve MTA1 promoter activity and expression, thereby inducing the resistance breast cancer cells to apoptosis (Figure 5).