MYC and neoplasm: (7) have shown that RBM38 acted as a tumor suppressor by inhibiting the expression of c-Myc via directly targeting the Ares in c-Myc mRNA 3’UTR, and thus destabilizing c-Myc transcript; In turn, c-Myc inhibits RBM38 expression by directly binding to the E-box motif in the promoter region of RBM38 gene.