Additionally, knockdown of endogenous SAM68 can inhibit cell proliferation and tumorigenicity of breast cancer cells by blocking G1 phase transition to S phase, which is related to upregulation of cyclin dependent kinase inhibitor p21 Cip1 and p27 Kip1, enhanced transactivation of FOXO factor and decreased Akt/GSK-3β signal transduction (2). The gene discussed is CDKN1A; the disease is breast cancer.