Increasing evidence showed that QKI may be a tumor suppressor in various malignant tumors, including colon cancer, lung cancer, oral cancer, and prostate cancer (70–73), for example, QKI impairs the self-renewal and EMT of oral squamous cell carcinoma cells (70–73); QKI can also regulate cell communication and inhibit the progression of clear cell renal cell carcinoma (74). This evidence concerns the gene QKI and malignant colon neoplasm.