Since oxaliplatin-resistant SNUC5 cells and cisplatin-resistant ovarian cancer cells express a high level of NRF2, inhibition of O-GlcNAcylation may potentiate the 5-FU-induced oxidative stress in these cells by decreasing NRF2 and HO-1 expression (84, 85). This evidence concerns the gene NFE2L2 and ovarian carcinoma.