The expressions of NAV1, SIPA1L2, FMN2, MMP28, SETBP1, EIF4E3, MICU3, and RUNX1T1 have shown to be decreased in CRC samples and reduced expression levels of SIPA1L2, MMP28, and EIF4E3 are associated with lower overall survival rates in CRC patients. The gene discussed is RUNX1T1; the disease is colorectal carcinoma.