G6PD and non-small cell lung carcinoma: To investigate effects of GDNPs on PPP metabolism in NSCLC cells, we added the effective antimetabolic drug aminonicotinamide (6-AN, G6PD inhibitor) and TP expression to investigate GDNP effects on cellular levels of NADPH and PPP rate-limiting enzyme G6PD and production of PPP intermediate metabolite R-5-P.