DNMT3A and acute myeloid leukemia: Overexpression of mutated DNMT3A1 or DNMT3A2V (a DNMT3A2 variant lacking 68 base pairs) in AML cells resulted in increased proliferation rates, while overexpression of normal DNMT3A1 or DNMT3A2 significantly reduced cell proliferation, thus strengthening the hypothesis that DNMT3A has a tumor suppressive role (133).