In contrast, DNA hypermethylation is mainly observed in the later stages of MM and this mainly in the CpG islands present in the promotor regions of tumor suppressor genes [including RASSF4, p15, p16, p73, TP53, SOCS1, DAPK, SFRP1, SFRP2, VHL, and EGLN3 (Table 3)] and enhancer regions of B-cell specific genes (including BCL11A, BATF, EBF1, and PAX5), causing inactivation of these genes (93–118). This evidence concerns the gene SOCS1 and Miyoshi myopathy.