ATF3 and cancer: In the present study, transcriptomic data revealed that 15 μM of sodium selenite targeted hallmark genes that support cancer progression, with significant downregulation of genes (CEMIP, PLOD2, DDR2, and P4HA1) associated with cancer cell survival, extracellular matrix remodeling, and metastatic potential, together with upregulation of cell death associated genes (ATF3 and ACHE) (40).