Sodium selenite treatment upregulated pro-apoptotic, apoptotic, and tumor suppressor genes such as ATF3, FOSB, GADD45B, DUSP8 and ACHE, and downregulated tumor cell survival genes such as SCD, LRP1, RAB31, SRPX2, PDK1 and CSGALNACT1. Here, DUSP8 is linked to neoplasm.