ACHE and cancer: Specifically, CEMIP, PLOD2, DDR2 and P4HA1, genes involved in cancer growth, extracellular matrix remodeling, and metastatic potential, were significantly downregulated, while the cell death-inducing genes ATF3 and ACHE were significantly upregulated in the tissue slices treated with Se15 μM as compared to untreated controls (Supplementary Table 2).