Sodium selenite treatment upregulated pro-apoptotic, apoptotic, and tumor suppressor genes such as ATF3, FOSB, GADD45B, DUSP8 and ACHE, and downregulated tumor cell survival genes such as SCD, LRP1, RAB31, SRPX2, PDK1 and CSGALNACT1. This evidence concerns the gene SRPX2 and neoplasm.