Specifically, CEMIP, PLOD2, DDR2 and P4HA1, genes involved in cancer growth, extracellular matrix remodeling, and metastatic potential, were significantly downregulated, while the cell death-inducing genes ATF3 and ACHE were significantly upregulated in the tissue slices treated with Se15 μM as compared to untreated controls (Supplementary Table 2). This evidence concerns the gene PLOD2 and cancer.