The interaction between β2 integrin of melanoma cells and ICAM1 of neutrophils was proven to mediate the combination of these two cells, which can deal with the damage of FSS (80).At the same time, melanoma cells were found to produce and secrete high levels of cytokine IL–8, which attracts neutrophils and increases the expression of β2 integrin in turn (81). This evidence concerns the gene CXCL8 and melanoma.