PIWIL2 and colorectal carcinoma: The overexpression of piRNA-54265 in HCT116 and LoVo cells promoted the formation of PIWIL2/STAT3/p-SRC complex by directly binding to PIWIL2, thereby activating the STAT3 signaling pathway, leading to the resistance of CRC cells to 5-FU and OXA (232).