CD274 and non-small cell lung carcinoma: Currently, ongoing clinical trials are testing anti-TIGIT mAb in combination with PD-1/PD-L1 therapy, including locally advanced or metastatic NSCLC (NCT03563716), advanced or metastatic solid cancers (NCT02913313), untreated locally advanced unresectable or metastatic NSCLC (NCT04294810), and more with a full list summarized in Table 9.