In a study targeting tumor-derived soluble NKG2D MIC molecules, simultaneously targeting sMIC with a PD-1/PD-L1 inhibitor resulted in enhanced infiltration, intrinsic function, and proliferation of CD8+ T cells with a TILs score recorded at 32.5% compared to 21% TILs of anti-PD-L1 monotherapy (152).. This evidence concerns the gene CD8A and neoplasm.