EGFR and non-small cell lung carcinoma: EGFR exon 18 G719, exon 19 K757R, exon 20 S768I, exon 21 G836S, and E746G mutations have been correlated to successful treatment outcomes in NSCLC patients, whereas tumors exhibiting exon 18 S720I mutation demonstrated poor clinical outcomes to erlotinib (52).