CD274 and non-small cell lung carcinoma: A study of 495 NSCLC patients treated with pembrolizumab monotherapy achieved an ORR of 19.4%, and a median duration of response of 12.5 months, leading to pembrolizumab was approved as a single agent for the first-line treatment for NSCLC patient with PD-L1 TPS ≥1% and without driver gene mutations (11).