Specifically, high expression levels of M1-related cytokines, such as TNF-α, TNFR1, IL-6, IL-8, NGF, VEGF, COX-2, MCP-1, PGE2, NLRP3, and IFN-γ, promote IDD. This evidence concerns the gene TNFRSF1A and intervertebral disk degenerative disorder.