TNFSF4 and colorectal carcinoma: Although these findings were unexpected given its association with poor prognosis in other cancer types, particularly in CRC (65), it was further verified that tumors with high F. nucleatum loads displayed low RNA levels of OX40 ligand (TNFSF4) and fibroblasts (PDGFRβ) (44), which predicted the favorable prognosis (66).