Similarly, the expression of lncRNA RP1−85F18.6 and ΔNp63 increased and GSDMD cleavage was suppressed in primary CRC, which suggests that the levels of lncRNA RP1−85F18.6, ΔNp63, and GSDMD-N domain should be highlighted diagnostically. This evidence concerns the gene GSDMD and colorectal carcinoma.