SIRT6 and Sepsis: found that the SIRT6 activator UBCS039 enhanced autophagy and M2 polarization in macrophages of a sepsis-induced ALI model, thereby reducing lung injury, while autophagy inhibitors eliminated this effect (157).The results found that SIRT6 overexpression restrained mTOR pathway activation, suggesting involvement of the mTOR pathway in SIRT6-regulated macrophage autophagy and M2 polarization (157).